The PEK/PERK (Ab-981) Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to EIF2AK3, PEK, and PERK. This antibody recognizes Human antigen. The PEK/PERK (Ab-981) Antibody has been validated for the following applications: Immunohistochemistry, and Western Blot.
Description
Phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1) By similarity.Shi Y., J. Biol. Chem. 274:5723-5730(1999).Sood R., Biochem. J. 346:281-293(2000).Delepine M., Nat. Genet. 25-406-409(2000)